Upon returning into Wakanda, T'Challa was officially crowned King, before he attempted to track down Ulysses Klaue, who had resurfaced after several years. However, T'Challa failed to capture Klaue and instead was forced to bring Everett Ross to the city to save his life. T'Challa's leadership was challenged when Erik Killmonger came into Wakanda, having killed Klaue and challenged T'Challa for their throne, as Killmonger bested T'Challa in a duel and took the crown. However, T'Challa had survived the duel and, with the help of M'Baku and his family, returned to Wakanda where he defeated Killmonger. Following the conflict, T'Challa returned to the United Nations as he had shared Wakanda's secret wealth with the rest of the world.
Black Panther was then called upon by the Avengers, as they had uncovered Thanos plan to claim all six Infinity Stones and wipe out half of all life in the universe. T'Challa agreed to allow the Avengers to keep Vision in the city, where Shuri could remove the Mind Stone. However, Wakanda was then invaded by Thanos' forces, as Black Panther had led his army against Thanos and the Black Order, only for them to be overpowered as Thanos completed his goal and then wiped out half of life, killing Black Panther as a result. However, Black Panther was resurrected five years later by Hulk, as he then joined the Avengers in a final battle against Thanos, finally defeating the Mad Titan, although Tony Stark sacrificed his life for victory.