The Mark 49 (XLIX), also known as "Hulkbuster Mark II", is an Extra Heavy Modular Armor, created by Tony Stark and Bruce Banner as a security safeguard in the event of an uncontrollable Hulk rampage, or other possible threats.

The armor was featured in Avengers: Infinity War, and it was used to fight against The Outriders and Thanos' Black Order.

Its design was completely based on the Hulkbuster Armor from the comics, confirming that this is the same armor with the same name as the one from the comics. The Mark 49 is extremely large in size. The armor has a dark red tone as its overall plating color, along with golden and silver plates in various areas of its structure. It is covered with layered pieces of metal and has multiple Arc Reactors around its body.

The Mark 49 is eleven feet tall, which currently makes it the second tallest armor and 3 feet taller than the Hulk. Aside from its height, it is also the second heaviest armor existing in the MCU.

The Hulkbuster Mark II is a Modular Armor.

Bruce Banner used it in the Battle of Wakanda.